Nivalin (galanthamine hydrobromide), an additional decurarizing agent. Some introductory observations.
نویسنده
چکیده
Galanthamine hydrobromide (Nivalin), an alkaloid from the bulbs of snowdrops, is widely used in Bulgaria as an antagonist to non-depolarizing muscle relaxants. The pharmacology is reviewed and experiences in the use of galanthamine in 24 patients are described. It is about one-tenth as potent as neostigmine. As changes in pulse rate and blood pressure were slight, it is rarely necessary to inject atropine before galanthamine. Salivation had to be suppressed by means of atropine in one-seventh of the cases. Detailed investigations are suggested.
منابع مشابه
Alkaloids from Hippeastrum papilio.
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkal...
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Galanthamine is an Amaryllidaceae alkaloid used to treat the symptoms of Alzheimer's disease. This compound is primarily isolated from daffodil (Narcissus spp.), snowdrop (Galanthus spp.), and summer snowflake (Leucojum aestivum). Despite its importance as a medicine, no genes involved in the biosynthetic pathway of galanthamine have been identified. This absence of genetic information on biosy...
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Galanthamine, an isoquinoline alkaloid and the current drug of choice for treatment of mild to moderate Alzheimer disease, is mainly obtained from Amaryllidaceae members. At present, the production of galanthamine from available natural plant sources is not sufficient to meet the demands of pharmaceutical industry. Additionally, overexploitation of the plant material leads to the depletion of a...
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 39 12 شماره
صفحات -
تاریخ انتشار 1967